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The U.S. Food and Drug Administration has approved the use of Contrave (naltrexone hydrochloride and bupropion hydrochloride extended-release tablets) to assist manage chronic obesity in older adults with a body mass index (BMI) of more than 27, given that they also experience weight-related health concerns such as Tupe2 diabestes, high cholesterol levels and/or hypertension (hypertension).Contrave is a combination of two FDA-approved drugs, naltrexone and bupropion, in the extended-release formulation. Naltrexone qualifies to treat alcohol and opioid dependence. Bupropion qualifies to treat depression and seasonal affective disorder and as an aid to smoking cessation treatment.'Obesity continues to be a major public health concern,' said Jean-Marc Guettier, M.D., director of the Division of Metabolism and Endocrinology Products in FDA's Center for Drug Evaluation and Research. 'When used as directed in combination using a healthy lifestyle that features a reduced-calorie dieting and exercise, Contrave provides another treatment selection for chronic weight loss for people who are obese or are overweight and possess at least one weight-related health problem.'The drug's effectiveness was evaluated in multiple many studies that included approximately 4,500 obese and overweight patients with and without significant weight-related conditions treated first year. All patients received lifestyle modification that consisted of a reduced- calorie diet and regular physical activity. Results from a clinical study that enrolled patients without diabetes established that patients had the average weight loss of four.1% instead of participants who have been given placebos) after a 12- month period, while a separate study involving patients with type 2 diabetes had a normal weight loss of 2% over treatment with placebo at one full year.

Using two separate drugs to lose weight naturally can be very effective you'll find combinations in front of the FDA now awaiting approval. When dealing with weight-loss and the people that go through it you need to err assisting caution and let the FDA do its job and demand some study be done so your public understands the side effects and hazards of the medications before we bring them. Keep in mind that drug companies come in business to earn money and that they would say almost anything to keep people on their own medications.

Researchers found out that participants taking this drug to get a year, lost weight within a month and have kept the extra weight off throughout the 56 weeks from the study. Contrave can be a combination of the drugs naltrexone and bupropion, which appears to reflect a whole new trend of weight-loss drugs which are made up of many active ingredient, which might make them more efficient and safer.

Combo-pilling could be the newest fad or in addition to this the newest ahead under scrutiny and thus it is just more publicly known although in the past, comb-pilling to lose weight has been around since the eighties. The biggest reason that utilizing a combination of pills is now popular will be the fact that at the time of right now there aren't long term prescription diet pills that have been approved by the FDA apart from orlistat. The truly disturbing part is always that doctors are prescribing these combinations of medications although some people might of the combinations are already rejected or have yet to be licensed by the FDA.

Seizures can be a side effect with Contrave and must not be taken in people who have seizure disorders. The drug can also raise blood pressure and heart rate, and mustn't be used in individuals with a history of cardiac arrest or stroke in the earlier six months. Blood pressure and pulse should also be measured before starting the drug and throughout therapy with the drug.

The FDA also warned that Contrave can raise blood pressure level and pulse rate and must stop used in patients with uncontrolled high blood pressure levels, and also by anyone with heart-related and cerebrovascular (circulation dysfunction impacting your brain) disease. Patients using a history of cardiac event or stroke in the last six months, life-threatening arrhythmias, or congestive heart failure were excluded through the clinical trials. Those taking Contrave must have their heart-rate and pulse monitored regularly. In addition, since compound includes bupropion, Contrave comes which has a boxed warning to alert physicians and patients to the increased chance of suicidal thoughts and behaviors related to antidepressant drugs. The warning also notes that serious neuropsychiatric events are actually reported in patients taking bupropion for quitting smoking.

An independent report published by Gant Daily in April also stated that naltrexone also works well with kleptomaniacs and gambling addicts, as well. Citing research in the University of Minnesota School of Medicine, Gant Daily reported that the drug creates kleptomaniacs and chronic gamblers just like with alcohol and opioid addicts'by blocking the consequences of endorphins, which the brain releases when experiencing craving or compulsions.